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Systemic Inflammatory Response Syndrome (SIRS) in Serious Chest Injuries: Is a Pharmacological Blockade Effective?
Authors: Havlíček Karel | Motyčka Vladimír | Šiller Jiří | Červinka Vladimír
Year: 2005
Type of publication: článek v odborném periodiku
Name of source: Annals of Thoracic and Cardiovascular Surgery
Page from-to: 232-237
Titles:
Language Name Abstract Keywords
cze SIRS u závažných poranění hrudníku. Je farmakologická blokáda efektivní? Článek se zabývá syndromem systémové zánětové reakce (SIRS) u závažných tupých poranění hrudníku a možnostmi farmakologické blokády SIRS indometacinem. V prvních 20 měsících průběhu studie bylo zařazeno 84 pacientů. Z dosažených výsledků lze říci, že určitá část pacientů by mohla profitovat z aplikace indometacinu. SIRS;MOF;Indometacin
eng Systemic Inflammatory Response Syndrome (SIRS) in Serious Chest Injuries: Is a Pharmacological Blockade Effective? Purpose: There has been an ongoing increase in the frequency and severity of blunt chest injuries. Their rather high lethality is caused by the injury alone as well as by the following systemic inflammatory response. The aim of the study is to verify the efficacy of the pharmacological blockade of the systemic inflammatory response syndrome (SIRS) in serious blunt chest injuries, and to identify whether the administration of indomethacin as a cyclooxygenase inhibitor could prevent a multiorgan dysfunction (MODS) and a multiorgan failure (MOF). Methods: Patients were divided into 4 Groups according to trauma severity - injury severity score (ISS) and into two subgroups ? an indomethacin subgroup where patients received indomethacin together with standard therapy, and a non-indomethacin subgroup. Results: Eighty-four patients were included in the study and 33 patients were given indomethacin. In Groups III and IV there was a later increase in inflammatory markers in patients treated with indomethacin. The elevation of inflammatory markers and the period of mechanical ventilation support in patients treated with indomethacin were shorter in Groups II and III. Seven (8.3%) patients died. Six of the seven dead patients were from the non-indomethacin subgroup. MOF was the cause of death in two patients in the non-indomethacin subgroup and in one patient in the indomethacin subgroup. Conclusion: The results obtained during the first 20 months of the study imply that a certain number of patients with serious blunt chest trauma could benefit from indomethacin administration. Lunt Chest Trauma;SIRS;MOF;indomethacin

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