Login for students

Login for employees

Publication detail

Kinetics of the immune response following pneumococcal PD conjugate vaccination.
Authors: Schuerman Lode | Prymula Roman | Chrobok Viktor | Dieussaert Ilse | Poolman Jan
Year: 2007
Type of publication: článek v odborném periodiku
Name of source: Vaccine
Publisher name: Elsevier Science
Place: Oxford
Page from-to: 1953-1961
Titles:
Language Name Abstract Keywords
cze Kinetika imunitní odpovědi po pneumkokové konjugované vakcíně. Primární vakcinace pneumokokovou kojugovanou vakcínou s D proteinem vede v prvním roce života k indukci ELISA a OPA odpovědi, které značně kolísají podle různých serotypů. Hladiny protilátek klesají po primární vakcinaci, ale byly zvýšeny po booster vakcinaci v druhém roce života. Hladiny protilátek klesly ve čtvtém roce života, ale byly vyšší než u neočkovaných dětí.
eng Kinetics of the immune response following pneumococcal PD conjugate vaccination. Primary vaccination with pneumococcal protein D conjugate vaccine in the first year of life induced clear ELISA and OPA responses, which varied considerably for the different serotypes. Antibody levels declined following primary vaccination but were restored (except for serotype 3) to above post-primary levels by booster vaccination in the second year of life. Antibody levels declined when measured in the fourth year of life, although remaining higher than in the non-immunized children. For some serotypes, antibody levels did not decline indicating exposure to pneumococci or cross-reacting bacteria. Development of natural immunity to several serotypes was evident from the increase in opsonophagocytic activity in the control group between booster and plain polysaccharide vaccination. Vigorous and rapid OPA and ELISA responses were elicited to all vaccine serotypes including serotype 3 following administration of plain polysaccharide vaccine in both the conjugate and control groups, being higher in the conjugate group (Study ID: 104083/NCT00169507). Pneumococcal Conjugate Vaccine;ELISA;Opsonophagocytic Activity.

Departments

Clinics

Map

en.mapy.cz

Services

Popular Links

© 2023 University of Pardubice, Studentská 95, 532 10 Pardubice 2
Phone: +420 466 036 111, 466 036 112, 466 036 113
Webmaster, RSS
Data box ID: f5vj9hu
Accessibility Statement
CC BY-NC-ND 4.0Creative CommonsAttributionNonCommercialNoDerivatives