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The fetal splenic vein flow pattern and fetal inflammatory response in the preterm prelabor rupture of membranes
Authors: Musilová Ivana | Kacerovský Marian | Andrýs Ctirad | Košťál Milan | Slabá Katarína | Jacobsson Bo
Year: 2014
Type of publication: článek v odborném periodiku
Name of source: Journal of Maternal-Fetal and Neonatal Medicine
Publisher name: Informa Healthcare UK
Place: London
Page from-to: 1-5
Titles:
Language Name Abstract Keywords
cze xx Objective: To evaluate the intensity of the fetal inflammatory response, characterized by umbilical cord blood IL-6 levels, and neonatal outcome in the preterm prelabor rupture of membranes (PROM) pregnancies using the pulsatile fetal splenic vein flow pattern. Methods: Women with singleton pregnancies complicated by PPROM at a gestational age between 24+0 and 36+6 weeks were included in the study. Doppler evaluation of the fetal splenic vein flow was performed. The flow-velocity waveform pattern was evaluated qualitatively as continous or pulsatile. The umbilical cord blood interleukin-6 (IL-6) levels were evaluated after delivery. The fetal infllammatory response was defined as IL-6>11pg/mL. Results: In total, 129 woman were inclided. The fetuses with pulsatile splenic vein flow exhibited hinher IL-6 levels in umbilical cord blood(median: 56.7pg/mL versus 5.6 pg/mL; p<0.0001) and had a higher rate of fetal inflammatory response syndrome (71% versus 35%; p=0.0005) than fetuses with continuous flow. The pulsatile flow pattern was related to a higher rate of early onset neonatal sepsis (odds ratio 4.2; 95% confidence interval:1.3-13.5).Conclusion: The presence of pulsatile fetal splenic vein flow in PPROM pregnancies is associated with fetal inflammatory response and neonatal morbidity. orgán plodu; předčasný porod; ultrazvuk
eng The fetal splenic vein flow pattern and fetal inflammatory response in the preterm prelabor rupture of membranes Objective: To evaluate the intensity of the fetal inflammatory response, characterized by umbilical cord blood IL-6 levels, and neonatal outcome in the preterm prelabor rupture of membranes (PROM) pregnancies using the pulsatile fetal splenic vein flow pattern. Methods: Women with singleton pregnancies complicated by PPROM at a gestational age between 24+0 and 36+6 weeks were included in the study. Doppler evaluation of the fetal splenic vein flow was performed. The flow-velocity waveform pattern was evaluated qualitatively as continous or pulsatile. The umbilical cord blood interleukin-6 (IL-6) levels were evaluated after delivery. The fetal infllammatory response was defined as IL-6>11pg/mL. Results: In total, 129 woman were inclided. The fetuses with pulsatile splenic vein flow exhibited hinher IL-6 levels in umbilical cord blood(median: 56.7pg/mL versus 5.6 pg/mL; p<0.0001) and had a higher rate of fetal inflammatory response syndrome (71% versus 35%; p=0.0005) than fetuses with continuous flow. The pulsatile flow pattern was related to a higher rate of early onset neonatal sepsis (odds ratio 4.2; 95% confidence interval:1.3-13.5).Conclusion: The presence of pulsatile fetal splenic vein flow in PPROM pregnancies is associated with fetal inflammatory response and neonatal morbidity. fetal organ; preterm delivery; ultrasound

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